Including this season, he hasn't appeared in more than 66 games since he won MVP in 2010-11.
This year, his first with the New York Knicks, had been going well.
Off-court legal issues and a sudden, random disappearance threw unexpected wrenches into his season, but Rose was generally productive for the Knicks in 64 games as he averaged 18 points and six assists per night.
This time, it's for a torn meniscus in his left knee, according to The Vertical. He will likely need a fourth knee surgery at the worst possible time as he's set to hit free agency this summer.
"I thought he's played well", Hornacek said.
Derrick Rose is done for the season after an MRI discovered a small tear in his meniscus.
Rose suffered the injury in Monday's game against the Pistons and was limping noticeably throughout much of the game.
Rose had begun the year healthy and talking about the Knicks as one of the NBA's "super teams".
Rose, who previously said he would like to return to NY, missed the Knicks' previous two games with what the team described as soreness and swelling. Carmelo Anthony, who has been in NY for the last seven seasons, may be with a new team next season, too.
The 28-year-old will be a free agent after this season, and a return to NY after this disastrous season is highly improbable.