As she received a lifetime achievement award from the Hollywood Foreign Press Association, the actress and TV star spoke of her humble upbringing and her childhood respect for civil rights heroes.
"And here's why. The media and the left in this country, well, they now seem to think Oprah is the one person that can help them fulfill their ultimate goal-to destroy Donald Trump and defeat President Trump", he added. The speech struck a chord, drawing comparisons to then-Illinois state senator Barack Obama's 2004 Democratic National Convention speech, which launched him toward the presidency four years later. When she ramped the energy and emotion even higher with her "new day is on the horizon" proclamation, I no longer had any doubt that I was hearing political oratory of a very high order.
Earlier in the evening, Winfrey had been asked to trim her speech by three minutes. Am I the only one that had that feeling?
"I slept on it and came to the conclusion that the Oprah thing isn't that insane", tweeted Dan Pfeiffer, a former senior advisor to Barack Obama, the president Winfrey was credited with helping to elect in 2008.
Taken from 2000's The America We Deserve, he said that Oprah would make an excellent vice president. But the famous television host does not plan to take up the challenge yet, according to King, who was pressed by colleagues on CBS This Morning to say whether she believes Winfrey will run.
With nearly three years to run, there is still all to play for in the 2020 presidential election.
Howard tweeted: "Probably the most extraordinary & inspiring moment I've ever witnessed at an award show". To which Trump replied: "Oprah, I love Oprah".
Harry Potter and The OA star Jason Isaacs also enthused about the speech, tweeting: "If you didn't watch Oprah elevating the art of communication and inspiration at the GoldenGlobes, get your children - get your daughters - and do yourselves a favour". Yes it is. May we all greet it with hope, resolve and faith. "I don't." But some close to her were quoted Monday saying she is thinking about it. Magnificent speech, magnificent career, magnificent woman!
This isn't the first time that Weight Watchers has been a beneficiary of Winfrey's clout.
During a 2008 rally for the candidate, Winfrey said she was "not here for partisan beliefs" and that over the years, she'd voted for as many Republicans as she had Democrats.