Tottenham strolled into the fourth round with a comprehensive 3-0 victory over AFC Wimbledon at Wembley.
The last time Tottenham lost to fourth-tier opposition was when they faced Russell Slade's Grimsby Town in September 2005.
It will mark a momentous occasion for the League Two side as they will be hosting an English top-flight side for the first time in over 30 years and irrespective of the result, the club and the fans will cherish the occasion.
Harry Winks and Serge Aurier are also both doubts vs. Newport: Winksy is still coming back from what appears to be a slow-healing ankle injury, and Aurier has a calf injury sustained in last weekend's 1-1 draw against Southampton. Will Mauricio Pochettino rest his star players? Joss Labadie and Matthew Dolan are not certainties for this tie.
Boss Mauricio Pochettino picks Michel Vorm in goal, while in defence he selects Jan Vertonghen and Juan Foyth as the central defensive pairing.
Adding further, Alderweireld said that Spurs have been in the top four teams every season which proves that the team is in the right direction. The full-backs are likely to be given plenty of freedom to run forward and Trippier has shown in the past that he can be extremely influential in such situations.
Eric Dier, Victor Wanyama and Moussa Sissoko slot into midfield, while Mousa Dembele plays.
Spurs arrive in excellent form and have just one defeat in 12 games - that 4-1 defeat to Manchester City back in December.
The two sides will be facing each other for the first time since consecutive cup meetings in 1959 and 1960, with Spurs winning both times.