An investigation is now underway on how an Amtrak passenger train ended up on the wrong track, causing a deadly crash with another train early Sunday morning in the USA state of SC.
The conductor and engineer aboard the Amtrak train were killed, the coroner's office said.
At least three patients were hospitalised in critical or serious condition, with almost all the rest treated for minor injuries such as cuts, bruises and whiplash.
Early reports show Amtrak train was diverted onto the side track where the CSX locomotive was parked by a rail switch that was supposed to prohibit traffic to the side rail, says Robert Sumwalt, chairman of the U.S. National Transportation Board (NTSB).
The two deceased were Amtrak personnel.
Jaclyn Kinney, 22, of Pinehurst, North Carolina, said she and her boyfriend were asleep on the train as they traveled to Orlando for a trip to Disney World.
Federal authorities say that a railway signaling system in SC was down for maintenance when an Amtrak train crashed into a CSX freight locomotive on Sunday, causing the deaths of an Amtrak engineer and conductor.
Sept, 29, 2016: A New Jersey Transit train plowed into a terminal in Hoboken, killing a woman standing on the platform and injuring 114 people.
Authorities said the freight train spilled 5,000 gallons of fuel, but hazmat teams were dispatched to the scene and determined the leak was not a danger to the public. "It was a tough scene", she said of the crash site.
Palmetto Health emergency room doctor Eric Brown said so many passengers were hurt that they were brought in on two buses, and a tent that had been set up as a waiting room to keep people separate from flu patients was turned into a triage area.
Anyone seeking info about passengers on Train 91 should call the Amtrak info line at 1-800-523-9101.
He said it appeared the Amtrak train had been on the wrong track at the time of the crash.
The southbound Amtrak train collided with a northbound CSX freight train, which was stationary, causing the Amtrak train to derail, according to Margaret Fisher.
"We know that they are shaken up quite a bit and this is unlike anything else they've ever been through before".
In a press conference the Governor praised the rapid response and hard work of all the first responders, as well as the Red Cross in giving aid and comfort to the victims.
A spokesman for the South Carolina Emergency Management Division said that injuries ranged from minor cuts to broken bones, Xinhua news agency reported.
President Donald Trump tweeted his condolences around midday.
Three people were killed and more than 70 others were hurt when a train careened off a bridge outside Tacoma, Washington, on Amtrak's inaugural run on a new route for its Cascades service on December 18. The truck driver was killed and six people were injured in the incident.