A day after his listening session, Trump convened another meeting on school safety.
LaPierre said, "Their goal is to eliminate the Second Amendment and our firearms freedoms, so they can eradicate all individual freedoms".
He said opponents of gun rights want to "sweep under the carpet" the failure of school safety, families, "and even the unbelievable failure of the FBI" to prevent the shootings. He criticized independent Vermont Sen.
"I'm not just talking about Bernie Sanders".
Pierre's appearance at the conference comes eight days after one of the most deadly school shootings in American history took place at Marjory Stoneman Douglas High School - a gun spree that left 17 dead and 14 injured.
Calling reports on gun reform a "breathless national media desperate to smear the NRA", and Black Lives Matter and Antifascist activists "gangbangers", LaPierre claimed that neither the Virginia Tech shooter or the San Bernardino shooter had a proper background check.
LaPierre said he wishes "more had heeded my words" after the Sandy Hook Elementary School shooting in 2012, when he called for more security in schools. "If they truly cared, what they would do is protect them", said LaPierre.
Mr LaPierre argued against interviewing buyers before they purchase a gun, and against restrictions on gun purchases in general.
It's also unclear whether Senate Minority Leader Chuck Schumer, a New York Democrat, is keen to expose his colleagues running for re-election in states Trump won in 2016 to a long series of gun votes. "Now I'm not saying that you love the tragedy but I am saying that you love the ratings".
The longtime face of the NRA was preceded on stage by the group's spokeswoman, Dana Loesch, a prominent conservative radio host.
President Donald Trump threw his support behind some of the solutions addressing gun violence that were brought to the table in a series of tweets Thursday morning. He spent Thursday morning tweeting about possible changes to gun control laws.
After the Vegas massacre, the NRA said it backed a ban on bump stocks.
"Congress is in a mood to finally do something on this issue - I hope!" he tweeted.
"I hear a lot of quiet in this room, and I sense your anxiety", LaPierre said, turning to the political consequences of the debate.
The comment came after Trump suggested on Twitter he wanted to overhaul the background checks system.
The President also went out of his way to praise LaPierre, before a speech that is likely to go down well with Trump's base but could strike those with more moderate political opinions as deeply divisive.
Like Trump, the NRA is attempting to discredit the Federal Bureau of Investigation. "They hate the NRA, they hate the Second Amendment, they hate individual freedom".